Handbook of Andrology (2nd Edition)
B. Robaire and P. Chan
LIST OF CONTRIBUTORS
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- What are the components of the male reproductive system?
CNS, pituitary, testis, epididymis, prostate, seminal vesicles, scrotum,
- What is the relationship among the various endocrine components
of the male reproductive system?
Hypothalamic-Pituitary-Testicular Axis, feedback loops
- How are communication signals read in the male reproductive
Receptors for gonadotropins and androgens
- What compounds mediate communication within the testis? Where
and how are male-associated hormones produced?
Integration of the hypothalamus, pituitary and testis
- How is the synthesis of testosterone regulated?
- How are germ cells produced and what factors control their
- What unique chromosomal events lead to the formation of a
haploid male germ cell?
- How is the production of spermatozoa regulated?
Hormonal regulation of spermatogenesis: role of androgens
- Are there epigenetic events associated with male germ cell
formation? What is the role of genomic imprinting in male germ
Imprinting, DNA methylation
- What does the epididymis do and how does it do it?
- What is the prostate and what are its functions?
- How does semen analysis assist in understanding the reproductive
status of the male?
- How is sperm chromatin structure assessed? What is the value of
doing such assessments?
Range of methods that assess sperm chromatin quality
- What is sperm banking? When and how is it (or should it be) used
in humans? Animals?
Sperm banking, consequences of its use in animal and clinical
- How does the sperm make its way to the egg and how does
fertilization take place?
Capacitation, acrosome exocytosis, steps of sperm-egg interaction,
J.P. Evans and J.L. Bailey
- What determines maleness?
Sex determination, testis formation and the development of the male
D.W. Silversides and R.S. Viger
- Are there specific genetic defects affecting the male reproductive
tract? What are the underlying molecular mechanisms?
Turner’s and Klinefelter’s syndromes, genetic loci, GnRH/LH/FSH,
steroid biosynthesis and androgen insensitivity
- Is there a trigger for puberty in the male? Should early or delayed
puberty be treated? If so, how?
T.M. Plant and S.F. Witchel
- Clinical male infertility: Epidemiology and basic evaluation
- Why evaluate the infertile male in the era of ART?
Medical and surgical therapies for male infertility
- What are the assisted reproductive technologies for male
Indications for IVF/ICSI/IUI, Surgical sperm retrieval techniques
- Are there genetic factors associated with male infertility?
- How can we assess the health outcomes in ART-conceived
Ethical issues in andrology
T.J. Walsh and M.S. Croughan
- How is male-factor subfertility minimized in companion and foodproducing
- What should I know about artificial insemination (AI) of animals?
R.P. Amann and D.L. Garner
- Is there a decline in sperm counts in men?
R.J. Sherins and G. Delbès
- How do environmental cues affect male reproductive?
- What are the effects of environmental toxicants and/or endocrine
disruptors on sperm function?
Chemical exposure effects on the male, reactive oxygen species and
- Can spermatozoa be targets for drugs? If so, what are the
consequences of such drug exposures? Is there a need for preconception
counselling for men?
Drugs that affect sperm structure or function, male-mediated
developmental toxicity, prevention, tests to detect damage to
B.F. Hales and B. Robaire
- Can we protect spermatogenesis against testicular insults?
Male reproductive toxicology
- What male contraceptives currently exist and what is the outlook
for new male contraceptives?
J.K. Amory and W.J. Bremner
- What are the consequences of sexually transmitted infections on
- What types of testicular cancers occur in men? What is their
prognosis? How effective are existing therapeutic approaches?
- How do erections occur? How common is erectile dysfunction,
what is its etiology, and how do you evaluate men with this
P.M. Pierorazio and A.L. Burnett
- How to treat erectile dysfunction?
M.C. Raynor and W.J.G. Hellstrom
- Is there an andropause, better known as Testosterone Deficiency
Syndrome, and if so, what tissues are affected and how?
Fertility, androgen production and sensitivity, osteoporosis and sexual
function in aging men
- Should there be hormone replacement therapy for aging men?
- What is the importance of psychosocial issues, counseling and
psychotherapy in andrology?
N. Hunt and S. McHale
- What is BPH?
- Are some men more susceptible to prostate cancer than others
and why? What are the treatments and their effectiveness? What
are the possibilities for improvements in therapy?
D.J. Parekh and I.M. Thompson
- What is the risk of testosterone therapy after prostate cancer?
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